Controlled Drug Release and Antibacterial Properties of Levofloxacin-Loaded Silk/Chitosan Green Composite for Wound Dressing

Antibacterial wound dressings have great importance to reduce infections caused by bacteria. In this research work, levofloxacin-loaded silk fibroin and chitosan composite scaffolds were synthesized for effective dressing applications. Initially, was degummed extraction of fibroin, it mixed with at different ratios. The stirred room temperature get soluble clear gel formation. Afterward, citric acid poured into the solution more 30 min a homogeneous solution. dried using vacuum oven 40 °C 48 h. Next, loaded levofloxacin HCL 24 h temperature. prepared characterized scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), fourier transform infrared (FTIR) spectroscopy. antibacterial activity evaluated agar disc diffusion method. results FTIR proved that cross-linked chitosan. SEM EDX demonstrated successful loading onto scaffolds. Moreover, scaffold samples confirmed sustained drug release properties. All an appropriate agent could effectively inhibit growth